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Provides standardized, high-quality services to support translational research, including pre-analytical biospecimen single-cell processing and isolation procedures, as well as analytical technologies.

The Biospecimen and Translational Genomics Core provides services in the areas of collection and banking of biological specimens, including assistance with regulatory document preparation and consenting, tissue processing for histology, DNA and RNA isolation from biological specimens with integrity analysis, SNP genotyping (high throughput and single) and absolute and relative quantification of RNA expression. The core also provides access to a BioRad real-time PCR system, BioRad droplet digital PCR system and Leica Aperio Versa 200 digital slide scanning system.

High-speed cell sorting of up to 4 subpopulations simultaneously, plate sorting of single-cell per well or desired number of cells per well, and multi-parameter (low to high) flow cytometry analysis for cellular profiling and deep immunophenotyping. 

Services include molecular mass determination, protein identification, global/discovery proteomics (identification and relative quantification), interactomics, identification of sites of protein modification, and targeted small molecule analysis, all using HPLC-electrospray ionization mass spectrometers with high mass resolution and accuracy.

Acquisition and analysis of optical data and imaging of living cells, tissues, and animals. 

Advanced, high-field NMR instrumentation and detailed 3-D x-ray crystallography analyses for structural studies of biological macromolecules.